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However, when combined with insulin or sulfonylureas, the risk of hypoglycemia increases substantially, potentially affecting twenty to thirty percent of patients if doses of concurrent medications are not appropriately adjusted

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Found primarily in the gut (the distal intestine), cells in the pancreas, and neurons of the central nervous system, this receptor plays a vital role in metabolic and hormonal balance that can support healthy glucose response throughout the body.* These hormones also help balance hunger, satiation, and energetics and thus affect metabolic processes for healthy glucose response